High-purity shark chondroitin sulfate is a key ingredient for joint health care
Chondroitin sulfate (CS) is an important glycosaminoglycan that is covalently linked to proteins to form proteoglycans. It is widely distributed in the extracellular matrix and cell surface of animal tissues, and is an important component of the animal connective tissue, which is especially abundant in cartilage. The basic structure of chondroitin sulfate is formed by alternating ligation of D-glucuronic acid and N-acetylgalactosamine by glycosidic bonds, which are further connected to the core part of the protein to form a complex proteoglycan structure.
Shark-derived chondroitin sulfate is one of them, which is an acidic mucopolysaccharide substance prepared from shark cartilage tissue. It appears as a white or white-like powder, no odor, neutral taste. Chondroitin shark sulfate is one of the main components of mammalian connective tissue, and it is widely found in cartilage, bone, tendons, ligaments, sarcolemma, and blood vessel walls.
It acts as a retention and support in the articular cartilage. Moderate intake of chondroitin sulfate can help maintain cartilage tissue, reduce swelling and pain, improve joint dysfunction, and have high safety. It is often used in conjunction with glucosamine, a combination that clinically significantly improves moderate to severe pain in osteoarthritis and stimulates new collagen and proteoglycans in chondrocytes.
| Product Name | Shark Chondroitin Sulfate Soidum |
| Origin | Shark Origin |
| Quality Standard | USP40 Standard |
| Appearance | White to off white powder |
| CAS Number | 9082-07-9 |
| Production process | enzymatic hydrolysis process |
| Protein Content | ≥ 90% by CPC |
| Loss on Drying | ≤10% |
| Protein Content | ≤6.0% |
| Function | Joint health Support, Cartilage and Bone Health |
| Application | Dietary supplements in Tablet, Capsules, or Powder |
| Halal Certificate | Yes, Halal Verified |
| GMP Status | NSF-GMP |
| Health Certificate | Yes, Health certificate is available for custom clearance purpose |
| Shelf Life | 24 months from production date |
| Packing | 25KG/Drum, Inner Packing: Double PE BAGS, Outer Packing: Paper Drum |
| ITEM | SPECIFICATION | TESTING METHOD |
| Appearance | Off-white crystalline powder | Visual |
| Identification | The sample confirm with the reference library | By NIR Spectrometer |
| The infrared absorption spectrum of the sample should exhibit maxima only at the same wavelengths as that of chondroitin sulfate sodium WS | By FTIR Spectrometer | |
| Disaccharides composition: The ratio of the peak response to the△DI-4S to the △DI-6S is no less than 1.0 | Enzymatic HPLC | |
| Optical Rotation: Meet the requirements for optical rotation, specific rotation in specific tests | USP781S | |
| Assay(Odb) | 90%-105% | HPLC |
| Loss On Drying | < 12% | USP731 |
| Protein | <6% | USP |
| Ph (1%H2o Solution) | 4.0-7.0 | USP791 |
| Specific Rotation | - 20°~ -30° | USP781S |
| Residue On Ingition (Dry Base) | 20%-30% | USP281 |
| Organic Volatile Residual | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| Chloride | ≤0.5% | USP221 |
| Clarity (5%H2o Solution) | <0.35@420nm | USP38 |
| Electrophoretic Purity | NMT2.0% | USP726 |
| Limite of none specific disaccharides | ＜10% | Enzymatic HPLC |
| Heavy Metals | ≤10 PPM | ICP-MS |
| Total Plate Count | ≤1000cfu/g | USP2021 |
| Yeast & Mold | ≤100cfu/g | USP2021 |
| Salmonella | Absence | USP2022 |
| E.Coli | Absence | USP2022 |
| Staphylococcus Aureus | Absence | USP2022 |
| Particle Size | Customized according to your requirments | In House |
| Bulk Density | >0.55g/ml | In House |
First, chondroitin sulfate is a glycosaminoglycan that is widely found on the extracellular matrix of tissues. In bone, it is mainly found in the periphery of chondrocytes and is an important component of the cartilage extracellular matrix. The substance helps the cartilage get water and nutrients, thus keeping the cartilage moist and elastic, and helping to maintain the normal function of the joints.
Secondly, the physiological effect of chondroitin sulfate is particularly important for the articular cartilage. It can bind water molecules, inhale water molecules into proteoglycan molecules, thicken the cartilage and increase the amount of synovial fluid in the joint cavity, lubricating and supporting the joint. In this way, the joint can reduce the friction and impact when moving, so that the joint can move more freely.
Finally, chondroitin sulfate also works in bone tissue engineering. The researchers have prepared composite hydrogels based on chondroitin sulfate, which autonomously bind inorganic ions and stimulate bone biomineralization, thus enhancing the regeneration capacity of bones. This has important applications for clinical orthopedic surgery such as bone defect repair and bone grafting.
1. Promote joint health: Chondroitin sulfate is one of the main components of the articular cartilage, which can help the articular cartilage to maintain its elasticity and water, and thus maintain the normal function of the joint. By supplementing with chondroitin sulfate, it can promote the repair and regeneration of articular cartilage, thus slowing down the process of joint degeneration.
2. Reduce joint pain: chondroitin sulfate can reduce the inflammatory response in the joint, reduce the stimulation of the joint synovium, and then reduce joint pain. This has a significant pain relief effect for patients with joint diseases such as arthritis.
3. Improve joint mobility: Chondroitin sulfate improves the mobility and flexibility of the joint by increasing joint lubrication and reducing joint friction. This makes the joint more smooth during movement, reducing the inconvenience caused by joint stiffness or limited movement.
4. Protect articular cartilage: Chondroitin sulfate can inhibit the degradation of articular cartilage, and promote the synthesis and secretion of chondrocytes, so as to play a role in protecting articular cartilage. This helps to delay the process of joint aging and degeneration.
1. Wound healing and skin repair: Chondroitin sulfate plays an important role in the process of wound healing. It can promote the regeneration and repair of wound tissue, improve the elasticity and tightness of the skin, and help to reduce scar formation. Therefore, chondroitin sulfate has potential applications in surgical procedures, burn treatment and skin repair.
2. Cosmetics industry: Due to its good moisturizing properties and anti-aging effect, chondroitin sulfate is also widely used in the cosmetics industry. It can be added to skin care products as a moisturizing ingredient, helping to maintain the skin moisture balance and improve the skin elasticity and gloss. In addition, chondroitin sulfate can also inhibit the production of free radicals, slow down the aging process of the skin, and make the skin younger and more healthy.
3. Tissue engineering and regenerative medicine: In the field of tissue engineering and regenerative medicine, chondroitin sulfate is used as a component of the construction of biomimetic stent materials. It can be combined with other biomaterials to form scaffolds with specific structures and functions for the repair or replacement of damaged tissues and organs. The biocompatibility and bioactivity of chondroitin sulfate make it an important candidate in the field of tissue engineering.
4. Antitumor effect: In recent years, studies have found that chondroitin sulfate also has antitumor potential. It can inhibit tumor initiation and progression by regulating the growth, differentiation and apoptotic processes of tumor cells. Although the relevant research is still in the preliminary stage, the application prospect of chondroitin sulfate in the field of anti-tumor is expected.
Chondroitin sulfate and glucosamine sulfate are not of the same species. There are some differences in their composition, use and mechanism of action.
Chondroitin sulfate is a glycosaminoglycan with a variety of biological activities, including lipid-regulating and anti-inflammatory effects. It is widely used in the treatment of osteoarthritis and is able to reduce inflammatory mediators and apoptotic processes, while simultaneously reducing the production of inflammatory cytokines, iNOS and MMPs. Moreover, chondroitin sulfate also plays an important role in the protection and repair of articular cartilage, helping the cartilage to resist tensile stress under various loading conditions by making the tissue resistant and elastic.
And glucosamine sulfate is another important compound, which is mainly used in the prevention and treatment of various types of osteoarthritis, such as the knee joint and hip joint. It acts on articular cartilage, by stimulating chondrocytes to produce proteoglycans with normal polysome structure, improve the repair ability of chondrocytes, inhibit damage cartilage enzymes such as collagenase and phospholipase A2, and can prevent the production of superoxidized free radicals in damaged cells, thus delaying the pathological process of osteoarthritis and the progress of the disease, improve joint activity, relieve pain.
Can I get some samples for testing?
Yes, we can arrange free samples, but please kindly pay for the freight cost. If you have a DHL account, we can send via your DHL account.
Does preshipment sample available?
Yes, we can arrange preshipment sample, tested OK, you can place the order.
What is your payment method?
T/T, and Paypal is prefered.
How can we make sure that the quality meets our requirments?
1. Typical Sample is available for your testing before placing the order.
2. Pre-shipment sample send to you before we ship the goods.
